Exploring selective neuronal vulnerability in Alzheimer’s disease – key pathways are downregulated in vulnerable subpopulations of RORB and CDH9 excitatory neurons of the entorhinal cortex at Braak 0
Our analyses suggest that changes in metabolic, ubiquitin-proteasome, and cell growth/survival pathways occur in vulnerable-like cells of the EC in BB0. Therefore, these pathways may be potential therapeutic targets in the earliest stages of AD. By looking into younger cohorts, we will further investigate if the molecular differences between these neuronal subpopulations are canonical (indicating a pathological predisposition) or an early pathological response.
Authors
- Lea T. Grinberg (ORCID: https://orcid.org/0000-0002-6809-0618)
- Renata Elaine Paraízo Leite (ORCID: https://orcid.org/0000-0002-5878-398X)
- Felipe Luiz Pereira (ORCID: https://orcid.org/0000-0001-9326-2365)
- Kun Leng (ORCID: https://orcid.org/0000-0001-9931-1375)
- Cláudia Kimie Suemoto (ORCID: https://orcid.org/0000-0002-5942-4778)
- Alexander Soloviev (ORCID: https://orcid.org/0000-0001-6519-1547)
- Martin Kampmann (ORCID: https://orcid.org/0000-0002-3819-7019)
Institutions
- Universidade de São Paulo (BR)
- University of California, San Francisco (US)
- University Memory and Aging Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091740
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00