Midlife Sensory and Motor Measures Among Best Predictors in Parsimonious Models of Long‐Term Cognitive Decline and Onset of Cognitive Impairment in Middle‐Aged Adults
In middle-aged adults, measures of sensory and motor function and NfL were among the best predictors of 10-year onset of cognitive decline and impairment and only 6 factors were needed to achieve acceptable to excellent AUCs. Cross-validation in another cohort is needed to verify these factors as reliable and valid predictors to identify those at high risk for neurodegeneration and cognitive decline who could benefit from early prevention and intervention strategies.
Authors
- Laura M. Hancock (ORCID: https://orcid.org/0000-0002-1016-5859)
- Corinne D. Engelman (ORCID: https://orcid.org/0000-0003-4750-5607)
- Richard J. Chappell (ORCID: https://orcid.org/0000-0002-3891-0881)
- Natascha Merten (ORCID: https://orcid.org/0000-0002-1405-1218)
- Carla R. Schubert (ORCID: https://orcid.org/0000-0001-8837-3394)
- Sterling C. Johnson (ORCID: https://orcid.org/0000-0002-8501-545X)
- Yanjun Chen (ORCID: https://orcid.org/0000-0003-4583-0027)
- A. Alex Pinto
- Adam J. Paulsen (ORCID: https://orcid.org/0000-0001-9919-0577)
Institutions
- Cleveland Clinic (US)
- University of Wisconsin–Madison (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.086737
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00