Variability in Reaction Time Predicts Transition to Mild Alzheimer Disease and is Sensitive to CSF Biomarkers in Cognitively Normal Older Adults
Variability in RT is a significant predictor of later development of cognitive symptoms associated with AD. Longitudinal changes in RT CoV are also sensitive to baseline amyloid status. These findings highlight the sensitivity of within-person fluctuations of attention as a cognitive biomarker for AD.
Authors
- Matthew S. Welhaf (ORCID: https://orcid.org/0000-0002-2826-5268)
- John C. Morris (ORCID: https://orcid.org/0000-0001-9820-5618)
- Suzanne E. Schindler (ORCID: https://orcid.org/0000-0002-1680-1465)
- Andrew J. Aschenbrenner (ORCID: https://orcid.org/0000-0002-4317-7282)
- David A. Balota
- Jason J. Hassenstab (ORCID: https://orcid.org/0000-0002-7802-3371)
Institutions
- Washington University in St. Louis (US)
- Prevent Alzheimer’s Disease 2020 (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087068
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00