A novel digital paradigm of orientation is associated with amyloid and tau among cognitively unimpaired individuals
We found associations between orientation in space and time, but not person, and amyloid and tau, even in this small sample of individuals who were cognitively unimpaired, in agreement with previous work, which has shown that orientation in space and time deteriorates earlier in the course of Alzheimer's disease than orientation in person. These results suggest disorientation to be a core cognitive impairment along the Alzheimer's disease continuum and may infer a role for routine assessment of orientation, assessed using a personally tailored digital tool, in early diagnosis of Alzheimer's disease.
Authors
- Amnon Dafni‐Merom (ORCID: https://orcid.org/0000-0001-7235-0286)
- Mark A. Dubbelman (ORCID: https://orcid.org/0000-0002-5708-4925)
- Gad A. Marshall (ORCID: https://orcid.org/0000-0002-9096-2355)
- Shahar Arzy
- Onyinye J. Udeogu
- Kathryn V. Papp (ORCID: https://orcid.org/0000-0003-1687-4370)
- Sharon X. Wang (ORCID: https://orcid.org/0000-0002-6937-9034)
- Uri Elias
- Rebecca England Amariglio (ORCID: https://orcid.org/0009-0009-5878-8930)
- P. E. S. Palmer
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Hebrew University of Jerusalem (IL)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.084246
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00