Path integration deficits are related to Alzheimer’s disease pathology
We detected a specific deficit in pure path integration in a virtual environment, in preclinical AD, suggesting a deficit to integrate self-motion cues. Furthermore, we decomposed the path integration performances into rotation and distance errors, and found that rotation errors were associated with MTL tauopathy, possibly reflecting impairment of grid cells; whereas distance errors mainly increased with older ages.
Authors
- Lara Huyghe (ORCID: https://orcid.org/0009-0009-3568-3474)
- Thomas Gérard (ORCID: https://orcid.org/0000-0001-7997-3945)
- Bernard Hanseeuw (ORCID: https://orcid.org/0000-0002-3102-6778)
- Lisa Quenon (ORCID: https://orcid.org/0000-0001-9139-2422)
- Nikolai Axmacher (ORCID: https://orcid.org/0000-0002-0475-6492)
- Lise Colmant (ORCID: https://orcid.org/0009-0006-6511-0819)
- Philippe Lefèvre (ORCID: https://orcid.org/0000-0003-2032-3635)
- Emilien Boyer (ORCID: https://orcid.org/0009-0009-6222-4580)
- Lukas Kunz (ORCID: https://orcid.org/0000-0002-0665-7703)
Institutions
- University Hospital Bonn (DE)
- Ruhr University Bochum (DE)
- UCLouvain (BE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.086877
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00