Hyperpolarization‐activated cyclic nucleotide‐gated channel inhibitor, Ivabradine, attenuates brain mitochondrial oxidative stress without reducing cognitive impairment in Dox‐induced chemobrain
Dox-induced chemobrain manifested in cognitive impairment, synaptic dysplasticity, and brain mitochondrial dysfunction. Iva treatment showed a reduction in brain mitochondrial ROS, with no improvement in mitochondrial membrane potential changes and swelling in Dox-induced chemobrain. Iva did not improve cognitive function and hippocampal-synaptic plasticity in Dox-treated rats. These findings suggest the antioxidant properties of Ivabradine in chemobrain, but this dose of Iva was not enough to protect brain injury in Dox-induced chemobrain.
Authors
- Nipon Chattipakorn (ORCID: https://orcid.org/0000-0003-3026-718X)
- Titikorn Chunchai (ORCID: https://orcid.org/0000-0003-4405-1208)
- Damrongsak Jinarat (ORCID: https://orcid.org/0009-0004-7203-5226)
- Busarin Arunsak (ORCID: https://orcid.org/0000-0002-5120-288X)
- Nattayaporn Apaijai (ORCID: https://orcid.org/0000-0002-1265-5210)
- Hiranya Pintana
- Adivitch Sripusanapan (ORCID: https://orcid.org/0009-0004-3338-1193)
- Chotrawee Piriyakunthorn
Institutions
- Chiang Mai University (TH)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.085164
- Citations
- 1
- Primary Topic
- Cancer-related cognitive impairment studies
- Type
- article
- Field-Weighted Citation Impact
- 0.42