Proteome‐wide analyses identifies plasma immune regulators of amyloid‐beta progression
Findings provide insights into how immune proteins in peripheral circulation influence the rate of Aβ accumulation, and identify specific peripheral immune mediators that may contribute to the progression of AD pathophysiology.
Authors
- Tonnar Castellano (ORCID: https://orcid.org/0009-0008-9480-5497)
- Susan M. Resnick (ORCID: https://orcid.org/0000-0003-1115-7145)
- Nicola Fattorelli (ORCID: https://orcid.org/0000-0001-5564-8179)
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Bart De Strooper (ORCID: https://orcid.org/0000-0001-5455-5819)
- Kaj Blennow (ORCID: https://orcid.org/0000-0002-1890-4193)
- Gabriela Gómez (ORCID: https://orcid.org/0000-0002-1761-0070)
- Renzo Mancuso (ORCID: https://orcid.org/0000-0002-7046-3348)
- Jingsha Chen
- Mary Ellen I. Koran (ORCID: https://orcid.org/0000-0002-3322-9114)
- Rebecca F. Gottesman (ORCID: https://orcid.org/0000-0002-9504-1256)
- Przemysław Radosław Kac (ORCID: https://orcid.org/0000-0001-5083-0924)
- Josef Coresh (ORCID: https://orcid.org/0000-0002-4598-0669)
- Luigi Ferrucci (ORCID: https://orcid.org/0000-0002-6273-1613)
- Michael R. Duggan (ORCID: https://orcid.org/0000-0002-1029-4423)
- Thomas K. Karikari (ORCID: https://orcid.org/0000-0003-1422-4358)
- Julián Candia (ORCID: https://orcid.org/0000-0001-5793-8989)
- Abhay Moghekar (ORCID: https://orcid.org/0000-0001-9464-1551)
- Madhav Thambisetty (ORCID: https://orcid.org/0000-0002-2200-2299)
- Alexandria Lewis (ORCID: https://orcid.org/0000-0002-3812-8080)
- Keenan A. Walker (ORCID: https://orcid.org/0000-0002-5989-9853)
- Anna Martínez‐Muriana (ORCID: https://orcid.org/0000-0002-8645-1317)
- Jenifer Cordon
- Murat Bilgel (ORCID: https://orcid.org/0000-0001-5042-7422)
- Nicholas J. Ashton
- Henrik Zetterberg
Institutions
- National Institutes of Health (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Vlaams Instituut voor Biotechnologie (BE)
- Profu (Sweden) (SE)
- National Institute of Neurological Disorders and Stroke (US)
- National Institute on Aging (US)
- University of Gothenburg (SE)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.084805
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00