Comprehensive Multi‐Neuron Imaging During Aging and Degeneration in <i>C. elegans</i>
Our work is defining the functional degradation of a complete nervous system from single neurons to system-wide dynamics during normal aging and in the disease model. In doing so we are revealing the specific changes in neuron activity at the cellular level that cause the breakdown of global nervous system dynamics. These results will enable a knowledge-based approach to novel neurotherapeutic strategies in the treatment and prevention of dementia.
Authors
- Gregory S. Wirak (ORCID: https://orcid.org/0000-0001-9645-1882)
- Christopher V. Gabel (ORCID: https://orcid.org/0000-0002-2763-3938)
- Dilip Kumar Yadav (ORCID: https://orcid.org/0000-0002-0232-7387)
- Christopher W. Connor (ORCID: https://orcid.org/0000-0003-1735-641X)
Institutions
- Boston University (US)
- Brigham and Women's Hospital (US)
- Harvard University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089961
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00