Cerebral vascular mitochondrial function is dependent on APOE genotype and estrogen status

Overall, these results indicate that APOE genotype modulates the impact of estrogen on the cerebrovasculature. We found that 17β-estradiol enhances cerebrovascular mitochondrial function in APOE3 mice but not APOE4 mice. The results suggest that estradiol supplementation may have more therapeutic benefit for APOE4 non-carriers.

Authors

Sherry A. Ferguson (ORCID: https://orcid.org/0000-0002-5120-0219)
Thomas W. Leonhardt
Mackenzie Kehmeier (ORCID: https://orcid.org/0000-0002-3328-8499)
Nabil J. Alkayed (ORCID: https://orcid.org/0000-0002-3489-4730)
Ashley E. Walker (ORCID: https://orcid.org/0000-0003-1612-4545)
Alexandra Famiano

Institutions

Oregon Health & Science University (US)
University of Oregon (US)

Publication Details

Journal: Alzheimer s & Dementia
Published: 2024-12-01
DOI: https://doi.org/10.1002/alz.090516
Primary Topic: Menopause: Health Impacts and Treatments
Type: article
Field-Weighted Citation Impact: 0.00

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article

Cerebral vascular mitochondrial function is dependent on APOE genotype and estrogen status

Sherry A. Ferguson, Thomas W. Leonhardt, Mackenzie Kehmeier, Nabil J. Alkayed et al.

Dec 1, 2024

Alzheimer s & Dementia

Menopause: Health Impacts and Treatments

article

Cerebral vascular mitochondrial function is dependent on APOE genotype and estrogen status

Sherry A. Ferguson, Thomas W. Leonhardt, Mackenzie Kehmeier, Nabil J. Alkayed, Ashley E. Walker, Alexandra Famiano

December 1, 2024article en

Abstract

Overall, these results indicate that APOE genotype modulates the impact of estrogen on the cerebrovasculature. We found that 17β-estradiol enhances cerebrovascular mitochondrial function in APOE3 mice but not APOE4 mice. The results suggest that estradiol supplementation may have more therapeutic benefit for APOE4 non-carriers.

Alzheimer s & DementiaVol. 20(S1)

Oregon Health & Science University (US), University of Oregon (US)

Good health and well-being

Openalex Percentile: Top 62%

Menopause: Health Impacts and Treatments

DOI Open Access PDF OpenAlex

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Cerebral vascular mitochondrial function is dependent on APOE genotype and estrogen status — Sherry A. Ferguson, Thomas W. Leonhardt, et al. · Alzheimer s & Dementia (2024) | TGRS Research Map | TGRS