Association Between Age and Cognitive Severity in Early‐Onset AD: Extension of preliminary findings in the Longitudinal Early‐Onset Alzheimer’s Disease Study (LEADS)
Building off preliminary work, our results suggest that executive functioning may be disproportionately impacted earlier in the disease course in participants with EOAD relative to other diagnostic groups. This finding appears to be unique to executive functioning, as it was absent in other cognitive domains and remained after accounting for disease severity. This highlights the need for further investigation into executive dysfunction early in the course of EOAD.
Authors
- Alexander Taurone
- María C. Carrillo (ORCID: https://orcid.org/0000-0003-3057-2387)
- Bonnie Wong (ORCID: https://orcid.org/0000-0002-1449-6938)
- Liana G. Apostolova (ORCID: https://orcid.org/0000-0003-1823-2451)
- Jeffrey L. Dage (ORCID: https://orcid.org/0000-0002-2192-1699)
- Gil D. Rabinovici (ORCID: https://orcid.org/0000-0002-3626-4265)
- Dustin B. Hammers (ORCID: https://orcid.org/0000-0002-1644-2618)
- Kelly Nudelman (ORCID: https://orcid.org/0000-0003-4040-1717)
- Ani Eloyan (ORCID: https://orcid.org/0000-0002-8110-7680)
- Bradford C. Dickerson (ORCID: https://orcid.org/0000-0002-5958-3445)
- Kala Kirby
- Maryanne Thangarajah
Institutions
- Alzheimer's Association (US)
- Harvard University (US)
- University of California, San Francisco (US)
- Brown University (US)
- Massachusetts General Hospital (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092663
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00