Exploring PACC5 Associations with Cortical Thickness in Individuals with Subjective Cognitive Decline
Adults with SCD trend toward a lower PACC5, presenting a reduced temporal CTh, an early atrophied region reported in neurodegenerative disorders, compared to the controls. Thinner left anterior and posterior CC and precuneus contributed to the lower PACC5 in SCD compared to controls. These results are relevant, as the CC role in resilience processes for cognitive impairment in AD is proposed, an aspect underexplored in SCD.
Authors
- María Cabello‐Toscano (ORCID: https://orcid.org/0000-0001-5066-3476)
- Lídia Mulet‐Pons (ORCID: https://orcid.org/0000-0002-8884-136X)
- Josep M. Tormos (ORCID: https://orcid.org/0000-0002-8764-2289)
- Lídia Vaqué‐Alcázar (ORCID: https://orcid.org/0000-0002-6776-6559)
- David Bartrés‐Faz (ORCID: https://orcid.org/0000-0001-6020-4118)
- Álvaro Pascual‐Leone (ORCID: https://orcid.org/0000-0001-8975-0382)
- Cristina Solé‐Padullés (ORCID: https://orcid.org/0000-0002-6653-1053)
- Kilian Abellaneda‐Pérez (ORCID: https://orcid.org/0000-0001-6447-1248)
- Gabriele Cattaneo (ORCID: https://orcid.org/0000-0002-7411-6829)
- Vanessa Alviarez‐Schulze (ORCID: https://orcid.org/0000-0002-9702-8688)
- Oriol Perera‐Cruz
- Javier Solana Sánchez (ORCID: https://orcid.org/0000-0003-0880-7856)
Institutions
- Universitat Autònoma de Barcelona (ES)
- Harvard University (US)
- Hospital de Sant Pau (ES)
- Valencia Catholic University Saint Vincent Martyr (ES)
- Institut Guttmann (ES)
- Hebrew SeniorLife (US)
- Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091218
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00