Unveiling the Pathogenic Influence of TDP‐43 on Tau‐Mediated Neurotoxicity in an Alzheimer’s Disease Mouse Model
This new mouse model provides a vehicle to explore causes and consequences of co-pathological tau and TDP-43. Further studies will be necessary to determine mechanisms underlying TDP-43 promotion of pathological accumulation of toxic Tau species and neuroinflammation in this experimental model of TDP-43- Tau co-expression.
Authors
- Pamela J. McMillan (ORCID: https://orcid.org/0000-0003-1243-1951)
- Misa Baum
- Sarah M. Waldherr (ORCID: https://orcid.org/0000-0002-8873-4185)
- Joshua C. Hincks (ORCID: https://orcid.org/0000-0001-7852-737X)
- Nicole F. Liachko (ORCID: https://orcid.org/0000-0003-1250-3871)
- Brian C. Kraemer (ORCID: https://orcid.org/0000-0002-2252-7634)
- Laura Garcia Toscano
Institutions
- University of Washington (US)
- VA Puget Sound Health Care System (US)
- Geriatric Research Education and Clinical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088566
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00