<i>APOE</i> rare missense variants in Japan
Through this survey, it became clear that there are RMVs of APOE that are unique to the Japanese population. In the future, we will expand the analysis to a discovery project on a scale of tens of thousands of individuals, including our subjects (n = approx. 2,500) collected so far. For the newly discovered RMVs, we plan to investigate their effects on the metabolism of amyloid beta and tau proteins in relation to AD.
Authors
- Norikazu Hara (ORCID: https://orcid.org/0000-0001-8525-3469)
- Takeshi Ikeuchi (ORCID: https://orcid.org/0000-0001-8828-8085)
- Tamao Tsukie
- Kensaku Kasuga (ORCID: https://orcid.org/0000-0002-2178-0769)
- M. Hasegawa (ORCID: https://orcid.org/0000-0001-9234-6014)
- Masataka Kikuchi (ORCID: https://orcid.org/0000-0002-9562-841X)
- Akinori Miyashita (ORCID: https://orcid.org/0000-0003-2508-9649)
- Ai Obinata
Institutions
- Niigata University (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088676
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00