Robust Symptomatic Subtypes of Typical Alzheimer’s Disease Characterized by Differential Neuropathological Patterns and Functional Decline
Our results challenge the concept of "typical" AD by uncovering five robust clinical phenotypes with divergent neuropathological profiles and clinical characteristics. These results mark an important advancement toward personalized medicine in the landscape of emerging AD treatments.
Authors
- Dana Tudorascu (ORCID: https://orcid.org/0000-0003-4675-3692)
- Peter Charles Lemaire (ORCID: https://orcid.org/0000-0002-8716-0466)
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- João Pedro Ferrari‐Souza (ORCID: https://orcid.org/0000-0003-2183-1551)
- Nicholas James Ashton (ORCID: https://orcid.org/0000-0002-3579-8804)
- Guilherme Povala (ORCID: https://orcid.org/0000-0002-2023-6569)
- Douglas Teixeira Leffa (ORCID: https://orcid.org/0000-0002-4890-8451)
- Ann D. Cohen (ORCID: https://orcid.org/0000-0001-7395-9624)
- Kaj Blennow (ORCID: https://orcid.org/0000-0002-1890-4193)
- Chang Hyung Hong (ORCID: https://orcid.org/0000-0003-3258-7611)
- Carolina Soares (ORCID: https://orcid.org/0000-0002-2338-4495)
- Sang Joon Son (ORCID: https://orcid.org/0000-0001-7434-7996)
- Guilherme Bauer‐Negrini (ORCID: https://orcid.org/0000-0003-0956-557X)
- Nesrine Rahmouni (ORCID: https://orcid.org/0009-0004-3081-8468)
- Pâmela C.L. Ferreira (ORCID: https://orcid.org/0000-0003-2134-9829)
- Matheus Scarpatto Rodrigues (ORCID: https://orcid.org/0000-0002-7794-6588)
- Victor L. Villemagne (ORCID: https://orcid.org/0000-0002-5832-9875)
- Bruna Bellaver (ORCID: https://orcid.org/0000-0002-2212-3373)
- Sarah Abbas
- Firoza Zubeida Lussier (ORCID: https://orcid.org/0000-0002-6877-4825)
- Cristiano Schaffer Aguzzoli (ORCID: https://orcid.org/0000-0002-7378-3830)
- Lívia Amaral (ORCID: https://orcid.org/0009-0005-4488-763X)
- Cécile Tissot (ORCID: https://orcid.org/0000-0003-2711-3833)
- Hussein Zalzale
- Francieli Rohden (ORCID: https://orcid.org/0000-0002-9232-7371)
- Pedro Rosa‐Neto (ORCID: https://orcid.org/0000-0001-9116-1376)
- Oscar L. López (ORCID: https://orcid.org/0000-0002-8546-8256)
- Markley S. Oliveira
- Marina Scop Madeiros
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- University of Pittsburgh (US)
- King's College London (GB)
- Instituto do Cérebro (BR)
- Ajou University Hospital (KR)
- McGill University (CA)
- Ajou University (KR)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091322
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00