Clinical Symptoms and Risk Factors in Older Adults with Limbic‐Predominant Age‐Related TDP‐43 Neuropathology in the Context of Mixed Dementia

In this study, head injury and greater years of education were identified as possible risk factors for LATE-NC. There were differences in the burden of neuropsychiatric symptoms between the two groups which require further investigation. However, the presence of LATE-NC did not appear to accelerate disease progression, suggesting its clinical impact is small relative to the impact of severe Alzheimer or Lewy Body pathology. Additional study including those with little or no concomitant pathology may help to elucidate the clinical phenotype further.