Elevated iron levels in the older adult brain are associated with higher R<sub>2</sub> relaxation rate in gray matter and more white matter hyperintensities: An ex‐vivo MRI, pathology and mass spectrometry study
This investigation combined ex-vivo MRI, neuropathology and mass spectrometry in a community-based older adults and showed that higher iron levels were independently associated with higher R<sub>2</sub> in gray matter and higher WMH burden.
Authors
- Sonal Agrawal (ORCID: https://orcid.org/0000-0003-2375-8888)
- Scott Ayton (ORCID: https://orcid.org/0000-0002-3479-2427)
- Julie A. Schneider (ORCID: https://orcid.org/0000-0002-9482-1752)
- Md Tahmid Yasar
- Ashley I. Bush (ORCID: https://orcid.org/0000-0001-8259-9069)
- Konstantinos Arfanakis (ORCID: https://orcid.org/0000-0001-9705-597X)
- Puja Agarwal
- David A. Bennett
Institutions
- Rush University Medical Center (US)
- The University of Melbourne (AU)
- Illinois Institute of Technology (US)
- Florey Institute of Neuroscience and Mental Health (AU)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.086010
- Primary Topic
- Trace Elements in Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00