[Molecular Mechanism of Protein C Deficiency Caused by Mutations of <i>PROC</i> Gene N355S, G392E, T314A].
The N355S, G392E and T314A mutations in the <i>PROC</i> gene cause functional defects in PC by weakening the binding between PC and substrate. These three mutations have caused serious spatial collisions in the protein structure, affecting the folding of PC and the reactivity of active sites.
Authors
- Lijun Xia (ORCID: https://orcid.org/0000-0002-9586-7971)
- Lulu Huang (ORCID: https://orcid.org/0009-0007-5709-6874)
- Jingjing Han (ORCID: https://orcid.org/0000-0001-5916-3187)
- Tianyi Li (ORCID: https://orcid.org/0000-0003-4994-1330)
- Miao Jiang (ORCID: https://orcid.org/0000-0002-3681-9494)
- Zhenni Ma
- Xia Bai
Institutions
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-12-01
- DOI
- https://doi.org/10.19746/j.cnki.issn.1009-2137.2024.06.030
- Primary Topic
- Vitamin C and Antioxidants Research
- Type
- article