Macrophage Migration Inhibitory Factor and Interleukin 1-β mRNA Levels as Predictors of Antidepressant Treatment Response in Major Depression
We did not replicate prior findings that pre-treatment expression levels for two cytokines predicted antidepressant treatment response. This raises questions about the clinical utility of using these biomarkers in treating depression.
Authors
- Hannah Roggenkamp
- Kevin G. Lynch (ORCID: https://orcid.org/0000-0002-0426-0323)
- L. Michelle Griffin
- Annjanette Stone (ORCID: https://orcid.org/0000-0001-8012-748X)
- David W. Oslin (ORCID: https://orcid.org/0000-0003-4392-4599)
- Henry R. Kranzler (ORCID: https://orcid.org/0000-0002-1018-0450)
- Michael E. Thase (ORCID: https://orcid.org/0000-0002-6403-0861)
- Steven A. Schichman (ORCID: https://orcid.org/0000-0002-6604-6226)
Institutions
- Veterans Health Administration (US)
- VA Connecticut Healthcare System (US)
- Central Arkansas Veterans Healthcare System (US)
- Philadelphia VA Medical Center (US)
- Department of Veterans Affairs (AU)
Publication Details
- Journal
- Psychopharmacology Bulletin
- Published
- 2025-08-12
- DOI
- https://doi.org/10.64719/pb.4509
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- Health Services Research and Development
- NIH Clinical Center