[The Preservation of HBV, HCV, HIV Viral Nucleic Acids in Plasma by Dry Spot Method and the Duration of Preservation].

The nucleic acids of the three common viral pathogens in blood samples, when preserved using the dry spot method, conform to a first-order reaction pattern in the accelerated degradation experiment. The relationship between the rate of nucleic acid degradation and the absolute temperature of storage is consistent with the Arrhenius equation. Based on the calculations using this equation, the stability and validity period of plasma nucleic acid samples preserved using the dry spot method can reach a minimum of 3.5 years under storage conditions not exceeding 20 ℃, which essentially meets the requirements for the preservation period of blood samples retained by blood banks.