[Synergistic Effect of IGF1-R Inhibitor AEW541 on Imatinib Inducing SUP-B15 Cell Death].
SUP-B15 cells treated with imatinib can establish drug tolerance. IGF1-R inhibitor AEW541 can further reduce STAT5 activation, thereby boosting the effect of apoptotic induction of imatinib on SUP-B15 cells. This research may provide a new idear to overcome imatinib tolerance.
Authors
- Wentong Guo
- Congyue Wang (ORCID: https://orcid.org/0009-0006-2133-4335)
- Jingjing Xi
- Chong Chen (ORCID: https://orcid.org/0000-0002-5035-4021)
- Nian Li (ORCID: https://orcid.org/0000-0003-4277-1471)
- Wenwen Zhang (ORCID: https://orcid.org/0000-0001-5226-1198)
- Xu Cao
Institutions
- Xuzhou Medical College (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-12-01
- DOI
- https://doi.org/10.19746/j.cnki.issn.1009-2137.2024.06.011
- Primary Topic
- Chronic Myeloid Leukemia Treatments
- Type
- article