Study of coagulation profile in non-hematological malignancy

Background: There is an increased susceptibility of thromboembolic events in malignancy as compared to benign diseases. Thrombosis might occur spontaneously, after surgery, radiation therapy and anticancer treatment. Over and above all it might be the first manifestation of underlying cancer. Cancer favors the activation of blood coagulation with the appearance of a hypercoagulable state or chronic DIC in these patients. Our aim of the present study to prevent complication arising from malignancy showing altered coagulation profile. Materials and Methods: Total 70 cases of non-hematological malignancy cases (histologically proven or by cytological examination) were studied over the period of 8 months in department of pathology who were admitted in SMIMER Hospital, Surat. Results: Out of 70 cases, most cases were having gastrointestinal, reproductive system and lung malignancies. In which gastrointestinal and respiratory malignancies with mucinous tumors showed increased prothrombin time, increased APTT along with positive FDP, increased fibrinogen and increased d-dimer. Conclusion: Altered coagulation parameters significantly correlate with aggressive behaviors of tumors and their metastatic possibilities. They are useful indicators of suspecting ICF syndrome (intravascular coagulation and fibrinolysis syndrome)