Coordination studies of Ritodrine Hydrochloride with selected transition Metal ions

The stability constants of binary complexes of metal ions Cu²⁺, Ni²⁺, Co²⁺, Cr³⁺ and Zn2+ with Ritodrine Hydrochloride ligand were studied in aqueous media at 280 C temperature. The Protonation constant and metal ligand stability constants were determined by Calvin Bjerrum titrations in combination with Microsoft excel software programme. 1 N NaNO3 used to maintain ionic strength. Metal ligand ratio kept was 1: 1. The Protonation constant and metal ligand stability constants calculated by half integral and pointwise method found to be in agreement. Protonation constant obtained were 9.42 and 9.72. The decreasing order of stability of the complexes found to be Zn (II) < Cu(II) < Co(II) < Ni(II) < Cr(III) which is accordance to Irving-Williams order. Application of inexpensively available HNO3, NaNO3 and natural media are the salient features of the work. The results provide new insights into the complexation of ritodrine and its biological significance.