Acute Respiratory Distress Syndrome in A 32-Year-Old Man with Newly Diagnosed Wegener’s Granulomatosis C-ANCA Positive Pauci Immune Crescentic Glomerulonephritis with Leucopenia Treated Successfully: A Rare Case Report

A 32-year-old man presented with myalgia, polyarthritis, hearing problem, sneezing, erythematous rash, episcleritis for one month. As serum creatinine was high, renal biopsy was done; it was compatible with pauci immune glomerulonephritis. Blood c-ANCA was positive; and, both anti-glomerular basement membrane antibody and p-ANCA were negative. Therefore, he was diagnosed as a case of Wegener’s Granulomatosis with rapidly progressive glomerulonephritis, and treated with corticosteroids, cyclophosphamide and rituximab. Hemodialysis was initiated shortly after immunosuppressive treatment as serum creatinine was rising. He developed dyspnea and low SaO2 due to acute respiratory distress syndrome (ARDS). Total WBC count was low (2.1X109 /L). He was successfully treated with continuous positive airway pressure (CPAP).

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Publication Details

Journal
International Journal of Medical Science and Clinical Research Studies
Published
2024-12-23
DOI
https://doi.org/10.47191/ijmscrs/v4-i12-57
Primary Topic
Vasculitis and related conditions
Type
article
Field-Weighted Citation Impact
0.00

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article

Acute Respiratory Distress Syndrome in A 32-Year-Old Man with Newly Diagnosed Wegener’s Granulomatosis C-ANCA Positive Pauci Immune Crescentic Glomerulonephritis with Leucopenia Treated Successfully: A Rare Case Report

Aung Htoo Kyaw, Chann Myei, Khin Phyu Pyar, Myo Thant Kyaw et al.
International Journal of Medical Science and Clinical Research Studies
Vasculitis and related conditions
article

Acute Respiratory Distress Syndrome in A 32-Year-Old Man with Newly Diagnosed Wegener’s Granulomatosis C-ANCA Positive Pauci Immune Crescentic Glomerulonephritis with Leucopenia Treated Successfully: A Rare Case Report

Aung Htoo Kyaw, Chann Myei, Khin Phyu Pyar, Myo Thant Kyaw, Sein Kyaw, Thurein Win, Aung Myint Thu, Kyaw Thet Maung, Aung Kyaw Myo, Nyan Lin Maung, Than Naing Lin, Thein Tun Myint, Zaw Min Tun, Zay Phyo Aung, Aung Phyoe Kyaw, Zar Ni Htet Aung, Tin Sein, Anne M Lynn, Soe Moe Htun, Sit Min, Soe Min Aung, Aung Htet, Aung Phyo Latt, Ohmar Hlaing, Han Lin Aung, Soe Win Hlaing, Saw Thar Wah, Myat Ko Ko, Naing Shin Htet, Soe Ko Ko Oo, Win Min Htun, Zaw Min Htwe, Aung Aung
article en

Abstract

A 32-year-old man presented with myalgia, polyarthritis, hearing problem, sneezing, erythematous rash, episcleritis for one month. As serum creatinine was high, renal biopsy was done; it was compatible with pauci immune glomerulonephritis. Blood c-ANCA was positive; and, both anti-glomerular basement membrane antibody and p-ANCA were negative. Therefore, he was diagnosed as a case of Wegener’s Granulomatosis with rapidly progressive glomerulonephritis, and treated with corticosteroids, cyclophosphamide and rituximab. Hemodialysis was initiated shortly after immunosuppressive treatment as serum creatinine was rising. He developed dyspnea and low SaO2 due to acute respiratory distress syndrome (ARDS). Total WBC count was low (2.1X109 /L). He was successfully treated with continuous positive airway pressure (CPAP).

International Journal of Medical Science and Clinical Research StudiesVol. 04(12)
National Defence Academy (IN), Military Hospital (PK), Ministry of Defence (NL), National Defence Medical Centre (CA), Associated Radiologists (US)
Ministry of Earth Sciences, Ministry of Education, India
Openalex Percentile: Top 56%
Vasculitis and related conditions
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