Balancing Immunity with a Dietary Supplement Derived from Five Edible Plants for Management of Diabetes

This study investigates the immunomodulatory effects of Diabenox/BIM-D, a dietary supplement derived from five edible plants, namely black sesame, guava fruit, mangosteen aril, pennywort leaves, and soy protein, on the regulation of T helper cell subpopulations. Twelve healthy volunteers were divided into two groups, one receiving a placebo and the other taking Diabenox/BIM-D capsules for 15 days. Blood samples were collected before and after the supplementation period, and peripheral blood mononuclear cells (PBMCs) were isolated and stimulated to assess cytokine production. In the present study, we demonstrated that Diabenox/BIM-D can modulate the immune cell functions by reducing the production of pro-inflammatory cytokines, including TNF-α, IL-5, IL-12 and IL-17. Diabenox/BIM-D is therefore suggested as the food supplement for balancing immunity in the management of diabetic patients.