Value of dynamic contrast-enhanced magnetic resonance imaging quantitative parameters in evaluating the efficacy of neoadjuvant chemoradiotherapy for cervical cancer

Background: this study focused on evaluating the effectiveness of dynamic contrastenhanced magnetic resonance imaging (DCE-MRI) in patients with cervical cancer (CC) undergoing neoadjuvant chemotherapy and radiation therapy.Materials and Methods: a total of 58 CC patients were included, undergoing examination through DCE-MRI scans.Subsequently, all cases were divided into two groups: the chemotherapy-effective group (32 cases) including complete response (CR) and partial response (PR), and the chemotherapy-ineffective group (26 cases) including stable disease (SD) and disease progression (PD).Results: after treatment, the average maximum diameter of tumors in the chemotherapy and radiation therapy failure group was 4.38 1.23 cm, drastically larger than the 2.510.64cm in the chemotherapy and radiation therapy response group (P < 0.05).Before treatment, the K trans of the chemotherapy and radiation therapy response group was superior to that of the failure group, while Ve was inferior to the latter (P < 0.05).After treatment, the K trans of the chemotherapy and radiation therapy response group decreased, showing a more drastic reduction compared to the failure group (P < 0.05).The K trans of the chemotherapy and radiation therapy response group was drastically inferior to that of the failure group, with statistical significance (P<0.05).The K trans % in the chemotherapy and radiation therapy response group was negative, inferior to pre-treatment values.In contrast, the K trans % in the chemotherapy and radiation therapy failure group was positive, superior to pre-treatment values (P < 0.05).Conclusion: DCE-MRI demonstrates excellent scanning performance for CC, accurately monitoring the blood flow signals of CC tumors.K trans , Ve, and K trans have high predictive value in neoadjuvant chemotherapy and radiation therapy.