Effect of Physiologic Insulin Resensitization on Stages of Chronic Kidney Disease

Chronic kidney disease (CKD) is common in diabetics. It is usually diagnosed after it has become symptomatic. Treatments of diabetes and CKD are for retarding the progress of the diseases. Reversal of established CKD seldom occurs. This paper presents the study of a treatment that reversed or stabilized CKD in diabetic patients. Twentyone diabetic patients with stages 3a,3b,4 and 5 CKD were treated with Physiologic Insulin Resensitiza-tion (PIR). The peak CKD stages prior to PIR treatment were determined and compared CKD stages at initia-tion of PIR. The Initial CKD stage at initiation of PIR was compared to the stage at the study end. Before starting with PIR. Twelve patient’s peak stage had worsened, 8 were stable and 1 improved. Of the PIR treated patients, 9 improved their stage, 10 were stable and 2 worsened over an average of 18 months. One of the stage 5 patients did not progress to needing dialysis after ten months. Patients with stages 3a, 3b, or 4 seldom reverse their CKD stages. It is remarkable that nine of 21 patients with CKD stages 3a, 3b and 4 improved their stages even though seven of them had a recent history of declining stages. The results have economic implications. As patient’s CKD worsens, treatment cost increases. Preventing stage 4 and 5 patients from progressing to needing dialysis or transplantation could result in hundreds of thousands of dollars in health savings.