Clinicopathological characteristics of breast cancer patients underwent radiotherapy with different genotypes in relation to the risk of recurrence

Background: This study aims to analyze the clinicopathological characteristics of breast cancer (BC) patients with different genotypes who underwent radiotherapy.The goal is to explore the relationship between these characteristics and the risk of recurrence, providing valuable insights for clinical adjuvant therapy.Materials and Methods: A retrospective analysis was conducted on pathological data of 256 BC patients who underwent surgical resection and radiotherapy.Data included age structure, tumor diameter and grading, estrogen receptor (ER) and progesterone receptor (PR) indicators, human epidermal growth factor receptor 2 (HER2), and the cell proliferation antigen marker (Ki-67).Multifactorial analysis was employed to assess correlations.Results: The distribution of BC patients in the low, medium-high, and high-risk groups was 70.9%, 23.2%, and 5.6%, respectively.Multifactorial analysis revealed that PR, Ki-67 expression, and histological grading were independent factors influencing the RS score, with corresponding P values less than 0.05.They were positively correlated (P < 0.001) with Ki-67 expression levels and tumor tissue grading, and negatively correlated with hormonal indicators.The short-term probability of survival for patients with the four staged BC in the low-risk group was 82.34%, 76.12%, 62.13%, and 60.23%, and 23.69%, respectively.Triple negative breast cancer (TNBC) patients and those with Luminal B BC exhibited a higher risk of metastasis (P < 0.05). Conclusion:The pathological characteristics of BC patients with different genotypes showed significant differences.TNBC patients and those with Luminal B BC should be particularly vigilant about their risk of recurrence and metastasis, and strengthen prognostic considerations.