Clinicopathology of Triple-negative Breast Cancer: A Study from Tertiary Care Hospital of Central India

Background: The triple-negative breast cancer (TNBC) is a unique molecular subtype of invasive ductal carcinoma that bears the characters of aggressive biological behavior, high Bloom Richardson grade, and high tumor, node, and metastasis (TNM) stage at its presentation. So also, young’s being affected by TNBC is more common. Therefore, a study has been undertaken at our center to evaluate TNBC for its clinicopathological characteristics. The objective of the study was to profile the TNBC for its clinicopathological features. Methods: The study design was observational. It was carried out on 36 patients who were diagnosed with molecular subtype of TNBC upon the immunohistochemistry for estrogen receptor, progesterone receptor, and human epidermal receptor 2. The descriptive statistics and statistical analysis for association of the selected clinicopathological characteristics with TNBC were performed. Results: The study was carried out on 36 patients. The 36.11% of these cases were below 40 years of age. The clinically palpable lymph nodes were noticed in 55.55% of the cases. Grade 3 disease was present in 58.33% of cases while tumor stage of T2 was noted in 63.88% of cases. The 44.44% patients had N1 + N2 disease. The lymphovascular invasion was noted in 55.55% cases. The TNM stage 2 and stage 3 diseases together was noticed in 94.46%. Conclusion: The single-center study of ours concludes that the molecular subtype of TNBC affects the young and shows the metastatic disease at its clinical presentation with high histological grade.