Functional germline variants in DNA damage repair pathways are associated with altered survival in adults with glioma treated with temozolomide
Functional germline alterations within DNA repair genes were associated with TMZ sensitivity, measured by overall survival among adults with glioma. These variants should be evaluated in prospective analyses and functional studies.
Authors
- Andrew Caleb Hsieh (ORCID: https://orcid.org/0000-0002-0897-1050)
- John K. Wiencke (ORCID: https://orcid.org/0000-0001-7101-6489)
- Stephen Francis (ORCID: https://orcid.org/0000-0002-6488-6272)
- Annette M. Molinaro (ORCID: https://orcid.org/0000-0002-9854-7404)
- Eduardo Rodriguez Almaraz (ORCID: https://orcid.org/0000-0003-0978-1117)
- Helen M. Hansen (ORCID: https://orcid.org/0000-0001-5456-4985)
- Geno Guerra (ORCID: https://orcid.org/0000-0001-9870-9998)
- Jeanette E. Eckel‐Passow (ORCID: https://orcid.org/0000-0002-6113-1114)
- Jennifer Clarke (ORCID: https://orcid.org/0000-0002-8054-7342)
- Lucie McCoy (ORCID: https://orcid.org/0000-0002-2728-6083)
- Linda Kachuri (ORCID: https://orcid.org/0000-0002-3226-4727)
- Robert B. Jenkins (ORCID: https://orcid.org/0000-0002-4049-694X)
- Margaret Wrensch (ORCID: https://orcid.org/0000-0002-3070-7600)
- Jean‐Baptiste Sallée (ORCID: https://orcid.org/0000-0002-6109-5176)
- George A. Wendt (ORCID: https://orcid.org/0000-0003-3608-9601)
- Jennie Taylor (ORCID: https://orcid.org/0000-0003-3980-5626)
- Victoria Guan
- Lianne Capistrano
- Veruna Kalsi
- Terri Rice
Institutions
- University of California, San Francisco (US)
- Stanford Health Care (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- Neurological Surgery (US)
- University of San Francisco (US)
- Stanford University (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2024-12-24
- DOI
- https://doi.org/10.1093/neuonc/noae275
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.44
Funders
- National Institutes of Health
- University of California, San Francisco
- National Heart, Lung, and Blood Institute
- National Institute of Mental Health
- National Institute on Drug Abuse
- National Human Genome Research Institute
- NIH Office of the Director
- National Cancer Institute
- National Institute of Neurological Disorders and Stroke
- Common Fund