Fabrication and Characterization of PVA/Tricalcium Phosphate/Quercetin Doped Silver Membrane for Guided Bone Regeneration

Periodontitis is a chronic inflammatory condition of the periodontal tissue caused by Aggregatibacter actinomycetemcomitans.Periodontitis eventually also leads to bone resorption.To treat it, biocompatible and wear resistant films/membranes have been introduced to enhance and boost the process of regeneration.Synthetic polymers are commonly used in tissue engineering as they have better mechanical characteristics.In this study, PVA nanofibers were incorporated with flavonoid doped silver oxide nanoparticles to facilitate bone regeneration and control infection and inflammation.The results indicated the successful formation of a membrane with nanofiber size of 100-150mm and pore size of 1-2 microns.The FTIR and XRD analysis proved the purity of the material.The contact angle test indicated the hydrophilicity of the membrane and the biocompatibility was found and confirmed by mtt assay and the osteoconductive ability of the membrane was observed.Hence this membrane proves to be successful in causing bone formation to a certain extent.