"Silkworm Haemolymph Plasma as a Natural and Sustainable Source of Anti-Microbial Peptides: AnEffective Alternative to Purification Techniques"

The use of Anti-Microbial Peptides (AMPs) as therapeutic agents has shown promise in the management of infectious disorders brought on by bacteria resistant to antibiotics. Purpose of this study was to isolate AMPs from the plasma of silkworm Bombyx mori (L) haemolymph and to study its antibacterial activity. The microbroth dilution assay was used to determine antibacterial action against strains of both Gram-positive and Gram-negative bacteria. Silkworm plasma had strong action against tested bacterial strain Bacillus licheniformis and Pseudomonas aeruginosa, according to the data. Whereas other bacterial strain Bacillus megaterium showed high resistance to Bombyx mori plasma. Addition to that the haemolymph plasma showed broad-spectrum action, suggesting that it could be a novel type of antibiotic activity. This study showed that AMPs with strong antibacterial activity are present in silkworm haemolymph plasma and showed an appealing substitute for purifying procedures when it comes to producing sustainable and natural sources of anti-microbial bio-chemicals because of its ease of use and affordability. These results may aid in the battle against antibiotic resistance and pave the way for the creation of new antibiotics. It is necessary to do additional research to determine the effectiveness of these AMPs in vivo and to consider their therapeutic uses.