FORMULATION AND EVALUATION OF ANTIDIABETIC TABLET FROM CNIDOSCOLUS ACONITIFOLIUS LEAF EXTRACT

Diabetes is a growing health concern worldwide, leading researchers to explore natural alternatives for managing blood sugar levels. Cnidoscolus aconitifolius, commonly known as Chaya Mansa, is a plant known for its potential antidiabetic properties. The purpose of this study was to create, develop and assess antidiabetic tablets from the leaf extract of Chaya Mansa. The study utilized the direct compression method to form the tablets and focused on optimizing their properties, particularly their physical characteristics and their effectiveness in managing Diabetes compared to the standard drug Acarbose. Various physicochemical properties were assessed. Preformulation studies were done to evaluate pre-compression parameters of powder blends. Compatibility of the drug with excipients was deterimined by FT-IR spectral analysis. Three different tablet formulations, labeled F1, F2, F3 were created using the direct compression method and then evaluated based on several physical properties & organoleptic characteristics. Additionally, the tablet formulations were tested for their in vitro anti diabetic activity using Alpha amylase enzyme inhibition method. However, among the three formulations, F3 emerged as the most promising candidate, demonstrating effective physical properties and superior in vitro anti diabetic activity compared to other formulations.