Plasma level of soluble glycoprotein IIb/IIIa in Beta-thalassemia major patients in relation to thrombotic risk score

Background: Multifactorial mechanisms are tangled in the pathogenesis of Thromboembolic events (TEE) in thalassemia major( TM) including the combination of the components of the hemostatic process together with the disease-specific features. GpIIb/IIIa is an integrin complex found on surface of platelets. It is a receptor for fibrinogen and prothrombin. Its activation leads to platelet aggregation. Aim: Estimate the plasma level of s GpIIb/IIIa in β- TM Subjects and methods: The study was conducted on 67 individuals divided into 2groups. The first group included 47 TM patients, while the second group included 20 healthy control subjects. complete physical examination , CBC, serum ferritin, CRP, and s GpIIb/IIIa by ELISA were done. Results The serum level of GpIIb/IIIa was significantly higher in the TM group with a p value Conclusion: TM are characterized by stronger platelet aggregation as reflected by increased GpIIb/IIIa which was associated with high , and intermediate TRT-RSS .