Immunohistochemical Analysis of ADAM8 Expression in Colorectal Adenocarcinoma

Introduction Colorectal cancer (CRC) is among the most commonly diagnosed cancers worldwide and ranks second after lung cancer as a leading cause of cancer-related deaths globally. In Egypt, it is the seventh most prevalent cancer. ADAM8, a type I transmembrane protein, possesses a complex multi-domain structure. Aim of the work In the present work, we investigated the immunohistochemical expression of ADAM8 in colorectal adenocarcinoma and its relationship with various clinicopathological features. Material and methods ADAM8&#039;s immunohistochemical expression was analysed in 70 CRC tissue specimens, and the expression of ADAM8 was correlated with the clinicopathological information of the patients. Results High expression of ADAM8 was detected in 52.9% of CRC cases. Statistically significant association between ADAM8 high expression and high TNM stage, advanced Modified Dukes stage, regional lymph node metastasis and tumor infiltrating lymphocytes (p<0.001, 0.001, <0.001 and 0.007 respectively). ADAM8 high expression did not appear to be associated statistically with any of the following factors: patients&#039; age, gender, primary tumor location, tumor’s size, tumor grade, PDCs, LNR, surgical margin status, tumor necrosis, Lymphovascular invasion and PNI (p = 0.341, 0.431, 0.204, 0.261, 0.223, 0.215, 0.546, 0.216, 0.2480.522, 0.127 respectively). In the 41 cases with positive lymph node metastasis, no significant correlation (p=1.00) was discovered between the expression of ADAM8 in the primary tumors and its expression in the corresponding lymph node metastasis. Conclusion The expression of ADAM8 was found to be significantly related to tumor infiltrating lymphocytes and unfavourable clinicopathological parameters, including lymph node metastasis and advanced tumor stage.