Folic Acid and Methyltetrahydrofolate Supplementation in the Mthfr677C>T Mouse Model with Hepatic Steatosis
MethylTHF and folic acid supplementation had limited benefits for TT mice, while folic acid supplementation had negative effects on CC females. Further investigation is required to determine if these effects are relevant in humans.
Authors
- Gareth R. Howell (ORCID: https://orcid.org/0000-0003-0565-6474)
- Alaina M. Reagan (ORCID: https://orcid.org/0000-0001-9666-0879)
- Olga Malysheva (ORCID: https://orcid.org/0000-0002-8626-5071)
- Jeanna Bennett‐Firmin
- Rima Rozen
- Teodoro Bottiglieri (ORCID: https://orcid.org/0000-0002-4199-7551)
- Karen E. Christensen (ORCID: https://orcid.org/0000-0003-1741-0375)
- Daniel Leclerc (ORCID: https://orcid.org/0000-0002-9766-8941)
- Marie A. Caudill (ORCID: https://orcid.org/0000-0002-7192-5743)
- Vafa Keser
- Yan Luan
- Marie-Lou Faquette (ORCID: https://orcid.org/0000-0001-7179-933X)
Institutions
- Cornell University (US)
- McGill University Health Centre (CA)
- Baylor Medical Center at Garland (US)
- Jackson Laboratory (US)
- Research Institute of Dallas (US)
- McGill University (CA)
Publication Details
- Journal
- Nutrients
- Published
- 2024-12-28
- DOI
- https://doi.org/10.3390/nu17010082
- Citations
- 2
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- McGill University Health Centre
- Canadian Institutes of Health Research