Antioxidant, Antiproliferative, Antibacterial, and Antimalarial Effects of Phenolic-Rich Green Tea Kombucha
Green tea kombucha, produced using a green tea (Camellia sinensis) grown in Brazil, was characterized and its in vitro bioactive properties were evaluated. Overall, 92 phenolic compounds were identified (70.7% flavonoids, 25% phenolic acids, 2.2% lignans, and 1.1% other polyphenols), contributing to the observed high antioxidant capacity. The major phenolics identified were gallocatechin, catechin 5-O-gallate, and epicatechin. Green tea kombucha exhibited antibacterial activity against all tested bacteria, being more effective against Salmonella spp. In addition, green tea kombucha demonstrated antimalarial activity against both chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum, and antiproliferative activity against cancer cell lines A549, HCT8, HepG2, and HUVEC. Additionally, it presented antioxidant properties by effectively reducing the generation of reactive oxygen species (ROS) and provided protection to erythrocytes against AAPH-induced oxidative stress. Thus, green tea kombucha is abundant in antioxidants and possesses intriguing bioactive properties that can be investigated by both the food and pharmaceutical sectors.
Authors
- Udielle Vermelho Lacerda (ORCID: https://orcid.org/0000-0003-3725-9027)
- Carolina Thomaz dos Santos D’Almeida (ORCID: https://orcid.org/0000-0003-4768-9071)
- Mariana Araújo Vieira do Carmo (ORCID: https://orcid.org/0000-0003-0069-2935)
- Frederico Augusto Ribeiro de Barros (ORCID: https://orcid.org/0000-0001-7300-8773)
- Vinícius Gonçalves Maltarollo (ORCID: https://orcid.org/0000-0001-9675-5907)
- Luciana Azevedo (ORCID: https://orcid.org/0000-0002-0502-4090)
- Amanda dos Santos Lima (ORCID: https://orcid.org/0000-0002-7919-8640)
- Alessio Giacomini (ORCID: https://orcid.org/0000-0003-4124-0142)
- Philipe Oliveira Fernandes (ORCID: https://orcid.org/0000-0001-8089-2958)
- Viviana Corich (ORCID: https://orcid.org/0000-0003-0774-665X)
- Mariana Simões Larraz Ferreira (ORCID: https://orcid.org/0000-0002-6043-0921)
- Cléber Thiago Ferreira Costa (ORCID: https://orcid.org/0000-0002-2977-4013)
- Monique Renon Eller (ORCID: https://orcid.org/0000-0002-5412-897X)
- Rodrigo Rezende Cardoso (ORCID: https://orcid.org/0009-0006-2161-9058)
- Laura da Silva Cruz
- Amanda Bubula de Souza
Institutions
- Universidade Federal de Minas Gerais (BR)
- University of Padua (IT)
- Universidade Federal de Viçosa (BR)
- Universidade Federal de Alfenas (BR)
- Universidade Federal do Estado do Rio de Janeiro (BR)
Publication Details
- Journal
- Beverages
- Published
- 2024-12-30
- DOI
- https://doi.org/10.3390/beverages11010007
- Citations
- 7
- Primary Topic
- Tea Polyphenols and Effects
- Type
- article
- Field-Weighted Citation Impact
- 2.97
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais
- Ministero degli Affari Esteri e della Cooperazione Internazionale