Research Progress on the Mechanisms of Neutrophil Extracellular Traps in Diabetic Wound Healing

Diabetes is a prevalent metabolic disease that poses a significant challenge to public health due to the development of difficult-to-heal skin ulcers in approximately one-quarter of patients. Neutrophil extracellular traps (NETs) are mesh-like structures released by neutrophils, initially believed to play a crucial role in combating microbial infections. However, an increasing body of research suggests that NETs also contribute to the pathogenesis of various diseases, including diabetic wounds. Studies have demonstrated that NETs can trigger excessive inflammatory responses, impede re-epithelialization and angiogenesis, and disrupt normal wound healing processes in individuals with diabetes. This article provides an overview of NETs, their mechanisms of action, and explores potential treatment strategies for diabetic wounds, aiming to offer novel insights for improving diabetic wound management.