Research Progress on NDUFA9 and GBM

Glioblastoma (GBM) is the most aggressive and deadly malignant glioma of the adult central nervous system (CNS), searching for related genes is very important for the treatment and prognosis of GBM. NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9 (NDUFA9) is a subunit of NADH: ubiquinone oxidoreductase (complex I), plays a significant rule in oxidative stress and metabolic reprogramming in a range of cancerous malignancies. Recently, it has been proved that NDUFA9 can predict prognosis and immunological status in GBM. NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (NDUFA4L2) is a subunit of complex I either which is similar to NDUFA9. Researchers demonstrate that in addition to being significantly upregulated in GBM tissues and cells, increased NDUFA4L2 expression has been found to be a reliable indicator of overall patient survival. Relevant studies on GBM have frequently referred to NDUFA9, as the subunit of the complex I in mitochondria, the mechanism of NDUFA9 on GBM may to do with the activities of mitochondria, oxidative phosphorylation pathway, the electron transfer chain and the production of ROS. However, the specific mechanism of NDUFA9 on GBM still lacks relevant reports and is required for further exploration.