Role of Increasing Body Mass Index in Gut Barrier Dysfunction, Systemic Inflammation, and Metabolic Dysregulation in Obesity
Together, these data demonstrated how an increased BMI led to significant changes in inflammatory markers, intestinal barrier metabolites, glucose metabolism, endocrine indicators, and fecal metabolomic profiles that can indicate a different metabolite production from gut microbiota. Our findings suggest that targeting intestinal permeability may offer a therapeutic approach to prevent and manage obesity and related metabolic complications, reinforcing the link between gut barrier function and obesity.
Authors
- Francesco Maria Calabrese (ORCID: https://orcid.org/0000-0003-0176-7046)
- Giovanni De Pergola (ORCID: https://orcid.org/0000-0003-0020-3273)
- Maria De Angelis (ORCID: https://orcid.org/0000-0002-2010-884X)
- Pasqua Letizia Pesole (ORCID: https://orcid.org/0000-0003-4675-2075)
- Fatima Maqoud (ORCID: https://orcid.org/0000-0002-4520-1370)
- Martina Di Chito (ORCID: https://orcid.org/0009-0007-2759-8347)
- Michele Linsalata (ORCID: https://orcid.org/0000-0001-7350-2544)
- Giuseppe Celano (ORCID: https://orcid.org/0000-0002-3805-7681)
- Domenica Mallardi (ORCID: https://orcid.org/0000-0002-0629-0972)
- Benedetta D’Attoma (ORCID: https://orcid.org/0000-0002-5416-3521)
- Gianluigi Giannelli (ORCID: https://orcid.org/0000-0002-5140-8060)
- Francesco Russo (ORCID: https://orcid.org/0000-0003-0538-6072)
- Carmen Aurora Apa (ORCID: https://orcid.org/0009-0002-4898-9850)
- Antonia Ignazzi (ORCID: https://orcid.org/0000-0003-4980-9997)
- Francesco Goscilo
- Arianna Diciolla
- Gabriele Bitetto
Institutions
- Gastroenterology Hospital "Saverio de Bellis" (IT)
- University of Bari Aldo Moro (IT)
Publication Details
- Journal
- Nutrients
- Published
- 2024-12-28
- DOI
- https://doi.org/10.3390/nu17010072
- Citations
- 12
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Ministero della Salute