Spatial proteomics reveals sirtuin 1 to be a determinant of T-cell infiltration in human melanoma
Our study deciphers the proteomics landscape in human melanoma, providing important information on the tumour microenvironment and identifying SIRT1 as having important prognostic and therapeutic implications.
Authors
- Fang Zhao (ORCID: https://orcid.org/0000-0002-2746-9242)
- Lars Borgards (ORCID: https://orcid.org/0009-0000-2362-4674)
- Christoph Krisp (ORCID: https://orcid.org/0000-0002-4689-1967)
- Devon Siemes (ORCID: https://orcid.org/0000-0003-1869-1930)
- Renáta Váraljai (ORCID: https://orcid.org/0000-0001-6852-6859)
- Batool Shannan
- Alexander Roesch (ORCID: https://orcid.org/0000-0002-0773-6067)
- Philippa Spangenberg (ORCID: https://orcid.org/0000-0002-5593-5546)
- Dirk Schadendorf (ORCID: https://orcid.org/0000-0003-3524-7858)
- Florian Rambow (ORCID: https://orcid.org/0000-0002-9727-8986)
- Iris Helfrich (ORCID: https://orcid.org/0000-0001-6150-9570)
- Alpaslan Tasdogan (ORCID: https://orcid.org/0000-0003-2543-852X)
- Franziska Hoffmann (ORCID: https://orcid.org/0000-0002-6872-924X)
- Selma Ugurel (ORCID: https://orcid.org/0000-0002-9384-6704)
- Daniel Robert Engel (ORCID: https://orcid.org/0000-0001-7301-353X)
- Camille Soun (ORCID: https://orcid.org/0000-0002-9993-158X)
- Ferdinand von Eggeling (ORCID: https://orcid.org/0000-0002-8062-6999)
- Sarah Scharfenberg (ORCID: https://orcid.org/0000-0001-9616-3493)
- Hartmut Schlueter
- Jenny Bottek
- Jan-Malte Placke
- Anette Paschen
Institutions
- Universität Hamburg (DE)
- German Cancer Research Center (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Essen University Hospital (DE)
- Jena University Hospital (DE)
- University of Duisburg-Essen (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1093/bjd/ljae433
- Citations
- 6
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- Deutsche Forschungsgemeinschaft
- Bristol-Myers Squibb Canada