Synthesis, Characterization and Antimicrobial Activity of Mixed-Ligand Metal Complexes of 4,4'-Bipyridine and Aniline-2,5-Disulfonic Acid

In this study, we prepared mixed-ligand Co(II) complex{[Co(ADSA)(BP)]n.2H2O, 1}, Ni(II) complex {[Ni(ADSA)(BP)]n, 2}, and Zn(II) complex {[Zn(ADSA)(BP)(H2O)2]n.3H2O, 3} of 4,4'-bipyridine (BP) with aniline-2,5-disulfonic acid (H2ADSA). The 1-3 were characterized by elemental analysis, AAS, TGA, IR, UV-Vis, molar conductivity and magnetic susceptibility techniques. Furthermore, the microdilution method was used to explore the antibacterial and antifungal activities of the initial and the synthesized metal complexes against the following bacteria and yeast: Pseudomonas aeruginosa, Escherichia coli, Enterococcus faecalis, Listeria monocytogenes, Staphylococcus aureus, Bacillus subtilis and Candida albicans. Antibacterial and antifungal activity results were compared with antibiotics (Vancomycin, Levofloxacin, Cefepime, Chloramphenicol, Fluconazole and Ketoconazole). Through the examination of the conducted studies, it was noted that the recently created compounds demonstrated efficacy in combating both bacterial and yeast infections.