Genetic modulators of diversity in biological expression of sickle cell anemia in patients from democratic republic of Congo
Background: So far, the fetal hemoglobin (HbF) level is the most recognized modulator of sickle cell anemia (SCA) clinical expression. Variability in the HbF levels is associated with the SCA haplotypes and quantitative trait loci identified by Genome-Wide Association Studies (GWAS). Key words: sickle cell anemia, DR Congo, SCA haplotypes, HbF, single nucleotide polymorphisms
Authors
- Mamy Ngole (ORCID: https://orcid.org/0000-0002-1041-9257)
- Gert Matthijs (ORCID: https://orcid.org/0000-0001-6710-1912)
- Aimé Lumaka (ORCID: https://orcid.org/0000-0002-5468-8678)
- Erika L. Souche (ORCID: https://orcid.org/0000-0001-9184-445X)
- Paul Kabuyi Lumbala (ORCID: https://orcid.org/0000-0003-2501-6765)
- Prosper Lukusa-Tshilobo (ORCID: https://orcid.org/0000-0002-5414-2915)
- Valérie Race
- Chris Van Geet (ORCID: https://orcid.org/0000-0003-1342-6265)
- Nono Mvuama
- Gloire Mbayabo (ORCID: https://orcid.org/0000-0002-6887-4092)
- Koenraad Devriendt (ORCID: https://orcid.org/0000-0002-3651-2548)
- Isabelle Cleynen (ORCID: https://orcid.org/0000-0003-0857-7683)
- Stephanie Deman
Institutions
- University of Kinshasa (CD)
- Center for Human Genetics (US)
- Centre Hospitalier Universitaire de Liège (BE)
- KU Leuven (BE)
Publication Details
- Journal
- Mediterranean Journal of Hematology and Infectious Diseases
- Published
- 2024-12-31
- DOI
- https://doi.org/10.4084/mjhid.2025.001
- Citations
- 2
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.88