Development and Evaluation of a Nanogel Formulation of Oxaprozin

The proposed work was aimed to Development and evaluation of a nanotechnology based formulation of oxaprozin. The preformulation studies for the chosen medication Oxaprozin include IR spectroscopy, melting point determination, and physical appearance analysis as methods of identification. It can be inferred from the Eudragit S-100 DSC overlay thermogram of the physical mixture and the pure drug demonstrates that the drug and excipients do not interact. According to Oxaprozin's UV spectra, the drug exhibits absorbances, with the highest absorbance occurring at 285 nm when the solution is made in methanol. Homogenicity, particle size, pH, drug content, in vitro drug release, skin irritation test, spreadability, extrudability, and viscosity were all optimized in the formulation of the nanogel. The drug content (±SD 98.9 ± 0.02), in vitro drug release (%), and spreadability (g.cm/s) of the optimized F7 formulation are 95.85 ± 0.0658 and 6.5 ± 0.3, respectively. 281 ± 0.5 is the extrudability (g). The viscosity of in cp at 50 (rpm) 9857 were found.