Whole-genome resequencing reveals collagen-related genes in Kele pigs
A total of 307 genes related to collagen traits were excavated, including COL9A1, COL6A5, EP300, SOS2 and EPO, etc. It was found that COL9A1 and COL6A5 genes were significantly expressed in the skin tissue of Kele pigs, and COL4A4 and COL4A3 genes were significantly expressed in the kidney tissue of Kele pigs. The mutations of 14 randomly selected loci in the four related genes were consistent with the results of previous whole genome resequencing analysis, indicating that the specific SNP molecular marker information obtained by whole genome resequencing can be used as the basis for analyzing collagen traits of Kele pig. Our results are conducive to further research on collagen trait regulation of Kele pigs and development and utilization of Kele pigs in the future.
Authors
- Huan Bi
- Xiao Yang (ORCID: https://orcid.org/0000-0003-0437-2015)
- Wei Yuan (ORCID: https://orcid.org/0000-0002-6866-4474)
- Liang Yu (ORCID: https://orcid.org/0009-0007-3922-3454)
- Yi Yu Zhang
- Wei Chen (ORCID: https://orcid.org/0000-0002-4807-205X)
Institutions
- Guizhou University (CN)
- Guizhou Academy of Agricultural Sciences (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1371/journal.pone.0311417
- Primary Topic
- Collagen: Extraction and Characterization
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science and Technology Program of Guizhou Province