Lactylation of tau in human Alzheimer's disease brains
Elevated tau lactylation, particularly at K331, is evident in in human AD brain samples. Lactate induces tau lactylation, enhancing phosphorylation and cleavage while inhibiting ubiquitination. The acetyl-transferase p300 catalyzes tau lactylation, with K331 being the most prominent site.
Authors
- Ning Wang (ORCID: https://orcid.org/0000-0003-4647-5880)
- Xiaoyu Zhang
- Yan Liu (ORCID: https://orcid.org/0000-0002-3961-9172)
- Michaella J. Rekowski
Institutions
- University of Kansas (US)
- The University of Kansas Cancer Center (US)
- University of Kansas Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1002/alz.14481
- Citations
- 22
- Primary Topic
- Biochemical effects in animals
- Type
- article
- Field-Weighted Citation Impact
- 7.18
Funders
- University of South Florida
- Kansas IDeA Network of Biomedical Research Excellence
- National Institutes of Health
- Cancer Center, University of Kansas
- National Cancer Institute
- National Institute of General Medical Sciences
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development