GC-MS Chemical Profiling, Antifungal and Antioxidant Activity of Cleome aspera Aerial Parts Extracts

Cleome aspera belongs to the Capparidaceae family. Many species of this family have been used in traditional folk medicine for a long period of time. This study aims to evaluate the antifungal and antioxidant properties of C. aspera and to identify various chemical constituents through GC-MS chemical profiling. In present study, aerial parts of Cleome aspera plant were extracted by petroleum ether, ethyl acetate and ethanol. In vitro, antifungal activity was investigated by agar disc diffusion method and minimum inhibitory concentration, whereas in vitro assay techniques, including total phenolic content (TPC) and total flavonoid content (TFC), were employed to evaluate antioxidant activity. Against all of the chosen strains, the ethanol (polar) extract showed prominent antifungal activity and had the strongest antioxidant activity, which is attributed due to the presence of significant levels of total flavonoids and phenolic contents. The findings indicate that the plant has considerable antioxidant and antifungal properties, along with a range of pharmacologically significant chemical compounds.