Roles of blood monocytes carrying TREM2 <sup>R47H</sup> mutation in pathogenesis of Alzheimer's disease and its therapeutic potential in APP/PS1 mice
TREM2<sup>R47H</sup> mutation compromises the Aβ phagocytosis of blood monocytes. Blood monocytes carrying TREM2<sup>R47H</sup> mutation contribute substantially to AD pathogenesis. Correction of the TREM2<sup>R47H</sup> mutation in bone marrow cells ameliorates AD pathologies and cognitive impairments.
Authors
- Yun‐Feng Tu (ORCID: https://orcid.org/0009-0001-3566-6051)
- Jiayan Xin (ORCID: https://orcid.org/0000-0001-9939-4609)
- Ying Wan (ORCID: https://orcid.org/0000-0001-7922-4434)
- Zilong Qiu (ORCID: https://orcid.org/0000-0003-4286-3288)
- Jie Liu (ORCID: https://orcid.org/0000-0002-5844-7900)
- An‐Yu Shi
- Yan‐Jiang Wang (ORCID: https://orcid.org/0000-0002-6227-6112)
- Qi Tan (ORCID: https://orcid.org/0000-0001-9504-5604)
- Tong‐Fei Liu (ORCID: https://orcid.org/0000-0002-3553-6871)
- Xian‐Le Bu (ORCID: https://orcid.org/0000-0002-2331-3339)
- Jinmei Tuo
- Shan Huang (ORCID: https://orcid.org/0000-0002-7375-5215)
- Zhongyuan Yu (ORCID: https://orcid.org/0000-0002-6664-5085)
- Li Ye (ORCID: https://orcid.org/0000-0001-7688-4867)
- Yuhui Liu (ORCID: https://orcid.org/0000-0001-7320-8353)
- Jun Wang (ORCID: https://orcid.org/0000-0001-6693-172X)
- Xiaoyu Liu (ORCID: https://orcid.org/0000-0003-3723-5711)
- Xiaowei Chen (ORCID: https://orcid.org/0009-0009-2079-8105)
- Yudi Bai (ORCID: https://orcid.org/0009-0006-5137-5138)
- Chang‐Yue Gao
- Yuanyuan Ma (ORCID: https://orcid.org/0000-0003-1082-7709)
- Gui‐Hua Zeng (ORCID: https://orcid.org/0009-0004-8158-9407)
- Jiali Li (ORCID: https://orcid.org/0000-0002-6297-4607)
- Zhihao Liu (ORCID: https://orcid.org/0009-0002-2665-3854)
Institutions
- Army Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Daping Hospital (CN)
- Center for Excellence in Brain Science and Intelligence Technology (CN)
- Songjiang District Central Hospital (CN)
- 181st Hospital of Chinese People's Liberation Army (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1002/alz.14402
- Citations
- 6
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.48
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China