Microstructural mapping of neural pathways in Alzheimer's disease using macrostructure‐informed normative tractometry
Changes in diffusion tensor imaging metrics may be due to macroscopic changes. Normative models encode normal variability of diffusion metrics in healthy controls. Variational autoencoder applied on tractography can learn patterns of fiber geometry. WM microstructure and macrostructure are modeled with multivariate methods. Transfer learning uses pretraining and fine-tuning for increased efficiency.
Authors
- Clifford R. Jack (ORCID: https://orcid.org/0000-0001-7916-622X)
- Robert I. Reid (ORCID: https://orcid.org/0000-0003-2391-8650)
- Himanshu Joshi (ORCID: https://orcid.org/0000-0003-2624-7821)
- Sophia I. Thomopoulos (ORCID: https://orcid.org/0000-0002-0046-4070)
- Neda Jahanshad (ORCID: https://orcid.org/0000-0003-4401-8950)
- Bramsh Q. Chandio (ORCID: https://orcid.org/0000-0002-8949-4937)
- Michael Weiner (ORCID: https://orcid.org/0000-0002-0877-4583)
- Ganesan Venkatasubramanian (ORCID: https://orcid.org/0000-0002-0949-898X)
- Emily Laltoo
- Yixue Feng (ORCID: https://orcid.org/0000-0003-1015-4209)
- Sebastian Benavidez
- John P. John (ORCID: https://orcid.org/0000-0001-6756-0297)
- Julio E. Villalón‐Reina (ORCID: https://orcid.org/0009-0005-9039-4924)
- Tamoghna Chattopadhyay (ORCID: https://orcid.org/0000-0002-3146-6845)
- Talia M. Nir (ORCID: https://orcid.org/0000-0002-7106-7443)
- Paul M. Thompson (ORCID: https://orcid.org/0000-0002-4720-8867)
Institutions
- University of Southern California (US)
- Mayo Clinic (US)
- University of California, San Francisco (US)
- National Institute of Mental Health and Neurosciences (IN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1002/alz.14371
- Citations
- 6
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.43
Funders
- Alzheimer's Association
- Department of Science and Technology, Ministry of Science and Technology, India
- National Institutes of Health
- National Institute on Aging