Systemic administration of induced pluripotent stem cell-derived mesenchymal stem cells improves cardiac function through extracellular vesicle-mediated tissue repair in a rat model of ischemic cardiomyopathy
Systemic administration of iPS-MSCs improved cardiac function through EV-mediated angiogenetic and antifibrotic effects in an ICM, suggesting the clinical possibility of treating chronic heart failure.
Authors
- Takuji Kawamura (ORCID: https://orcid.org/0000-0002-1155-3116)
- Iichiro Shimomura (ORCID: https://orcid.org/0000-0002-0851-9603)
- Shunbun Kita (ORCID: https://orcid.org/0000-0002-8937-0053)
- Maki Takeda (ORCID: https://orcid.org/0000-0002-6434-8992)
- Ryo Kawasumi
- Yuji Tominaga (ORCID: https://orcid.org/0000-0003-3832-4919)
- Akima Harada
- Kizuku Yamashita
- Emiko Ito
- Shigeru Miyagawa
Institutions
- The University of Osaka (JP)
Publication Details
- Journal
- Regenerative Therapy
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1016/j.reth.2024.12.008
- Citations
- 3
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Osaka University
- Japan Society for the Promotion of Science
- Research Institute for Microbial Diseases, Osaka University