A Rare Case of Diffuse Large B‐Cell Lymphoma With <i>MYC</i> and <i>BCL2</i> Gene Translocations Diagnosed Due to Temporomandibular Joint Symptoms

ABSTRACT Background Double‐hit lymphoma shows a poor prognosis, necessitating early diagnosis to improve prognosis. Case Presentation A 68‐year‐old Japanese woman presented with pain and a click in the right temporomandibular joint. The right side of her neck was acutely swollen. A biopsy of a mass lesion and lymph node suggested diffuse large B‐cell lymphoma; chromosomal analyses revealed MYC and BCL2 rearrangements. Complete response was achieved with chemotherapy. Peripheral blood stem cell transplantation was performed, but the patient relapsed. She died due to respiratory failure. Conclusion Double‐hit lymphoma is often accompanied by cervical lymphadenopathy. Lymph node biopsy is useful for early diagnosis.